Ms. X. is a 36-year-old woman without any psychiatric history, including abuse of alcohol, consumption of illegal drugs, or regular consumption of medication. She reported a depressed mood that lasted 2 weeks. She had to cry very often, without any trigger. Furthermore, she suffered from loss of concentration, a high sleep requirement, ruminations, anhedonia, and a reduced libido. Her mother suffered from a recurrent depressive disorder, and her father was addicted to alcohol. According to the described pathology above, the patient fulfilled the DSM-IV criteria for a major depression. Because of her emotional discomfort, anhedonia, and reduction in libido, an antidepressant pharmacotherapy with 150 mg daily bupropion, extended release, was launched. Ten days later, Ms. X. reported that, upon starting the medication regimen, she had been overly sensitive to stimuli such as noise. Furthermore, she had been anxious, had a headache, and tachycardia. Six days after taking the bupropion extended release she noticed gustatory and olfactory hallucinations. For example, a meal with chicken would have tasted of liver, while her office, as well as the waiting room of her general practitioner, would have smelled intensely of her boss's perfume, even though he had been on vacation that week. Orientation and concentration were unremarkable. Delusions and disorders of ego did not emerge. She continued the medication, and, after 2 days, the pathology disappeared. The bupropion level in serum during the follow-up appointment was 65.0 ng/ml (standard value: 50 ng/ml–450 ng/ml). Six weeks later, at a follow-up appointment, Ms. X. did not report any further side effects of the medication. Further diagnostic procedures such as MRI were declined by the patient.