A 39-year-old male patient from an urban background visited the Department of Psychiatry for the complaints of excessive yawning and vague anxiety symptoms. The patient had been alcohol-dependent for 10 years, but had quit the habit 6 years ago. Later, he had anxiety symptoms after renouncing alcohol intake. For the complaint of anxiety, he consulted a private psychiatrist 1 year earlier. Initially, he was given venlafaxine capsules, 37.5 mg/day. Then the dose was increased up to 150 mg/day over 2 weeks. Later, the patient returned with decreased anxiety symptoms, but at the same time, there was excessive yawning just after starting the drug, which worsened as the dose was increased. So he again visited the same private psychiatrist, where it was suggested to taper the dose. After 6 months, he was asked to stop the drug. There was a reduction in yawning after tapering the dose, and symptoms completely stopped once the drug was withdrawn. After 15 days of withdrawal, he had a recurrence of anxiety symptoms, and, once more, the private psychiatrist restarted venlafaxine at 75 mg/day. Once again, he had excessive yawning, and he reported to our department. His personal drug history was taken, and other causes for yawning were ruled out. As the patient did not have any specific anxiety or depressive disorders, he was advised to taper and finally to stop venlafaxine. Later, he was treated with relaxation and behavioral therapy and was asked to follow up. The patient has been free from yawning and anxiety symptoms for the last 3 months.