A 17-year-old boy was suffering from tension-type headache along with mild episodic anxiety symptoms. His past, family, and personal history were nonsignificant. There was no history to suggest depressive features. He was started on fluoxetine 20 mg per day along with relaxation exercises. The patient followed up after a period of 3 weeks with complaints of decreased need for sleep, talkativeness, over-familiarity, increased activity levels, and demanding behavior for the past 4 days. On examination, he had increased psychomotor activity, euphoric affect, racing thoughts, grandiose ideas, and inflated self-esteem. No other significant history was elicited. All his biochemical parameters, including CT head scan, were normal. Diagnosis of fluoxetine-induced hypomania was made. Fluoxetine was stopped, and clonazepam 1 mg was started. The patient improved in hypomanic symptoms in a week's time. He was then followed up, and he continued reporting headache. Amitriptyline was started, gradually increased to 25 mg per day. The patient has been maintained on this dose for the last 8 months without any recurrence of hypomania.