Traditional aphasia research and practice focus narrowly on language assessment and treatment, and regard the evaluation and treatment of neuropsychiatric disturbances as the province of mental health clinicians. This perspective, as well as the limitations of patient-based neuropsychiatric assessment,1 offers at least a partial explanation for these practice and research patterns. However, aphasia and neuropsychiatric disturbances independently and adversely affect stroke outcomes and functional status.1 Their co-occurrence may further compromise post-stroke disability. Accordingly, there is a clear need for further study and clinical consideration of the co-occurrence of aphasia and neuropsychiatric disturbances. Use of the NPI–NH as an assessment for post-stroke, aphasia-associated neuropsychiatric disturbances may allow progress toward those ends. This informant-based measure yields quantitative findings that complement patient interview, observation, and examination. As in our patient, the NPI–NH identifies functionally-relevant stroke sequelae in a manner that is acceptable to patients and their caregivers. Data yielded by the NPI–NH permit study of the relationships between post-stroke aphasia, neuropsychiatric disturbances, communication effectiveness, and disability. Further study of the NPI–NH for these purposes in this population is warranted.