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Clinical and Research ReportsFull Access

Preliminary Study of the Association of White-Matter Metabolite Concentrations With Disease Severity in Patients With Huntington’s Disease

Published Online:1 Jan 2014https://doi.org/10.1176/appi.neuropsych.13020040

Abstract

Proton magnetic resonance spectroscopy is used to measure several metabolites in cortical gray and white matter in patients with Huntington’s disease. The preliminary results show that CAG-repeat length correlates with white-matter N-acetylaspartate concentrations, and disease severity correlates with several metabolites.