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Clinical and Research Reports   |    
Comparison of Cognitive Functioning Among Individuals With Treated Restless Legs Syndrome (RLS), Untreated RLS, and No RLS
Hochang Benjamin Lee, M.D.; Christine M. Ramsey, B.S.; Adam P. Spira, Ph.D.; Jacqueline Vachon, M.S.; Richard Allen, Ph.D.; Cynthia A. Munro, Ph.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:87-91. doi:10.1176/appi.neuropsych.12120394
View Author and Article Information

From the Dept. of Psychiatry at Yale University, New Haven, CT; Dept. of Mental Health, Johns Hopkins Bloomberg School of Public Health; Depts. of Neurology and Psychiatry and Behavioral Sciences at the Johns Hopkins University School of Medicine, Baltimore, MD.

Send correspondence to Hochang Benjamin Lee, M.D.; e-mail: hochang.lee@yale.edu

Copyright © 2014 by the American Psychiatric Association

Received December 07, 2012; Revised March 18, 2013; Revised April 05, 2013; Accepted May 14, 2013.

Abstract

Restless legs syndrome (RLS) is a common neurological sensory-motor condition. High prevalence of comorbid depression and anxiety has been reported, but the few available data on the impact of RLS on cognition have been conflicting. The authors compared 91 participants (No-RLS group: N=37; Untreated RLS group: N=23; Treated RLS group: N=31) on cognitive performance and depression ratings. There were minimal observed group differences in cognitive performance, but the untreated RLS group had significantly higher depressive symptoms than the treated RLS and the no-RLS groups. RLS does not appear to affect cognition, but there does appear to be a strong association between untreated RLS and depression.

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TABLE 1.Sociodemographic Characteristics for No-RLS, Untreated RLS, and Treated RLS (Restless Legs Syndrome), mean (standard deviation)
Table Footer Note

*Significant (p <0.01) difference with No-RLS group.

Table Footer Note

Significant (p <0.01) difference with Untreated RLS group.

Table Footer Note

Significant (p <0.01) difference with Treated RLS group.

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TABLE 2.Psychological Variables for No-RLS, Untreated RLS, and Treated RLS, mean (standard deviation)
Table Footer Note

HVLT: Hopkins Verbal Learning Test; BVMT: Brief Visuospatial Memory Test.

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*Significant (p <0.01) pairwise difference with No RLS group.

Table Footer Note

Significant (p <0.01) pairwise difference with Untreated RLS group.

Table Footer Note

Significant (p <0.01) pairwise difference with Treated RLS group.

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