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Long-Term Duloxetine Withdrawal Syndrome and Management in a Depressed Patient
Yi-Cheng Hou, MSc; Chien-Han Lai, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:E04. doi:10.1176/appi.neuropsych.12110265
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Department of Nutrition, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan, ROC

Corresponding author: Chien-Han Lai, M.D. Department of Psychiatry, Cheng Hsin General Hospital, Taipei City, Taiwan, ROCe-mail: stephenlai99@gmail.com

Copyright © 2014 by the American Psychiatric Association

An erratum to this article has been published | view the erratum

Extract

To the Editor: Serotonin and norepinephrine reuptake inhibitors (SNRIs), such as venlafaxine,1 have been reported to be associated with withdrawal syndromes. However, duloxetine-related withdrawal syndrome is infrequently mentioned. We want to report on a depressed patient who experienced a long-term duloxetine withdrawal syndrome and relief after gradual tapering procedures.

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References

Agelink  MW;  Zitzelsberger  A;  Klieser  E:  Withdrawal syndrome after discontinuation of venlafaxine.  Am J Psychiatry 1997; 154:1473–1474
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Perahia  DG;  Kajdasz  DK;  Desaiah  D  et al:  Symptoms following abrupt discontinuation of duloxetine treatment in patients with major depressive disorder.  J Affect Disord 2005; 89:207–212
[CrossRef] | [PubMed]
 
Abdy  NA;  Gerhart  K:  Duloxetine withdrawal syndrome in a newborn.  Clin Pediatr (Phila) 2012; 52:976–977
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Carter  NJ;  McCormack  PL:  Duloxetine: a review of its use in the treatment of generalized anxiety disorder.  CNS Drugs 2009; 23:523–541
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Baboolal  NS:  Venlafaxine withdrawal syndrome: report of seven cases in Trinidad.  J Clin Psychopharmacol 2004; 24:229–231
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