0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Letters   |    
Benzodiazepine-Induced Coma in the Treatment of Severe Acute Mania
Julien Elowe, M.D.; Marie-Agathe Zimmermann, M.D.; Michel Hasselmann, M.D., Ph.D.; Jean-Marie Danion, M.D., Ph.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:E09-E10. doi:10.1176/appi.neuropsych.12120387
View Author and Article Information

The authors report no financial or other relationship relevant to the subject of this article.

Service de Psychiatrie I – Pôle de Psychiatrie et de Santé Mentale
Service de Réanimation Médicale
Hôpitaux Universitaires de Strasbourg
Strasbourg cedex, France

e-mail: Dr. Elowe; julien.elowe@gmail.com

Copyright © 2014 by the American Psychiatric Association

Extract

To the Editor: The management of bipolar disorders remains a considerable challenge in psychiatry, especially when taking into consideration the lifetime prevalence of these debilitating conditions which range from 0.7% to 6% in the general population,1,2 depending on the various clinical criteria, and their impact on functional outcome, underpinned by cognitive impairment and various psychosocial disabilities.3 Mortality is also increased in bipolar patients,4 accounted for both by a higher suicide rate5 and by the occurrence of diverse medical comorbidities such as cardiovascular and respiratory conditions.6 Acute mania remains a crucial characteristic phase of bipolar disorder, and its treatment is of particular interest. Indeed, a recent review has identified 11 pharmacological agents that have proven anti-manic efficacy, but a complete remission of symptoms is rare.7 In refractory and severe cases, electroconvulsive therapy (ECT) is also recommended.8

Figures in this Article

First Page Preview

View Large
/>
First page PDF preview
Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
 
Username
Password
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

+

References

Narrow  WE;  Rae  DS;  Robins  LN  et al:  Revised prevalence estimates of mental disorders in the United States: using a clinical significance criterion to reconcile 2 surveys’ estimates.  Arch Gen Psychiatry 2002; 59:115–123
[CrossRef] | [PubMed]
 
Judd  LL;  Akiskal  HS:  The prevalence and disability of bipolar spectrum disorders in the U.S. population: re-analysis of the ECA database taking into account subthreshold cases.  J Affect Disord 2003; 73:123–131
[CrossRef] | [PubMed]
 
Harvey  PD;  Wingo  AP;  Burdick  KE  et al:  Cognition and disability in bipolar disorder: lessons from schizophrenia research.  Bipolar Disord 2010; 12:364–375
[CrossRef] | [PubMed]
 
Müller-Oerlinghausen  B;  Berghöfer  A;  Bauer  M:  Bipolar disorder.  Lancet 2002; 359:241–247
[CrossRef] | [PubMed]
 
Bostwick  JM;  Pankratz  VS:  Affective disorders and suicide risk: a reexamination.  Am J Psychiatry 2000; 157:1925–1932
[CrossRef] | [PubMed]
 
Osby  U;  Brandt  L;  Correia  N  et al:  Excess mortality in bipolar and unipolar disorder in Sweden.  Arch Gen Psychiatry 2001; 58:844–850
[CrossRef] | [PubMed]
 
Sachs  GS;  Dupuy  JM;  Wittmann  CW:  The pharmacologic treatment of bipolar disorder.  J Clin Psychiatry 2011; 72:704–715
[CrossRef] | [PubMed]
 
Mukherjee  S;  Sackeim  HA;  Schnur  DB:  Electroconvulsive therapy of acute manic episodes: a review of 50 years’ experience.  Am J Psychiatry 1994; 151:169–176
[PubMed]
 
Young  RC;  Biggs  JT;  Ziegler  VE  et al:  A rating scale for mania: reliability, validity and sensitivity.  Br J Psychiatry 1978; 133:429–435
[CrossRef] | [PubMed]
 
Chouinard  G;  Young  SN;  Annable  L:  Antimanic effect of clonazepam.  Biol Psychiatry 1983; 18:451–466
[PubMed]
 
Jobling  M;  Stein  G:  Lorazepam in resistant mania.  Lancet 1986; 1:510
 
Dai  WS;  Xue  S;  Yoo  K  et al:  An investigation of the safety of midazolam use in hospital.  Pharmacoepidemiol Drug Saf 1997; 6:79–87
[CrossRef] | [PubMed]
 
Ziegler  G;  Ludwig  L;  Klotz  U:  Effect of midazolam on sleep.  Br J Clin Pharmacol 1983; 16(Suppl 1):81S–86S
[CrossRef] | [PubMed]
 
Hudson  JI;  Lipinski  JF;  Frankenburg  FR  et al:  Electroencephalographic sleep in mania.  Arch Gen Psychiatry 1988; 45:267–273
[CrossRef] | [PubMed]
 
References Container
+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Related Content
Books
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 5.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 5.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 5.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 42.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 10.  >
Topic Collections
Psychiatric News
PubMed Articles