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Fatal Neuroleptic Malignant Syndrome Induced by Clozapine in Parkinson’s Psychosis
Joana Mesquita, M.D.; Luisa Siva, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:E34. doi:10.1176/appi.neuropsych.13020028
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Psychiatry and Mental Health Department1
Hospital de Braga, Braga, Portugal

Correspondence: Dr. Mesquita; e-mail: slcmm.joana@gmail.com

Copyright © 2014 American Psychiatric Association


To the Editor: Psychotic symptoms, especially visual hallucinations, are common in Parkinson’s disease (PD). They can appear as a possible side effect of dopaminergic medication, or in the context of processes inherent to the disease itself, as the result of complex mechanisms integrating visual input processing and interpretation through limbic and temporal regions.1

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Bertram  K;  Williams  DR:  Visual hallucinations in the differential diagnosis of parkinsonism.  J Neurol Neurosurg Psychiatry 2012; 83:448–452
Casamassima  F;  Lattanzi  L;  Perlis  RH  et al:  Neuroleptic malignant syndrome: further lessons from a case report.  Psychosomatics 2010; 51:349–354
Kuchibatla  SS;  Cheema  SA;  Chakravarthy  KS  et al:  A case report of neuroleptic malignant syndrome.  BMJ Case Rep 2009
Yacoub  A;  Francis  A:  Neuroleptic malignant syndrome induced by atypical neuroleptics and responsive to lorazepam.  Neuropsychiatr Dis Treat 2006; 2:235–240
Pereira  YDS;  Srivastava  A;  Cuncoliencar  BS  et al:  Resolution of symptoms in neuroleptic malignant syndrome.  Indian J Psychiatry 2010; 52:264–266
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