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Letters   |    
A Case of Neurosyphilis Presenting With Dementia and Psychiatric Symptoms
Zeynep Baran Tatar, M.D.; Alparslan Cansiz, M.D.; Ayhan Köksal, M.D.; Erhan Kurt, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:E39-E40. doi:10.1176/appi.neuropsych.13020036
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Dept. of Psychiatry
Bakirkoy Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery
Istanbul, Turkey

Dept. of Psychiatry
Bakirkoy Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery
Istanbul, Turkey

Dept. of Neurology
Bakirkoy Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery
Istanbul, Turkey

Dept. of Psychiatry
Bakirkoy Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery
Istanbul, Turkey

Correspondence: Dr. Tatar; e-mail: drzeynepbaran@gmail.com

Copyright © 2014 by the American Psychiatric Association

Extract

To the Editor: Neurosyphilis is a clinical type of tertiary syphilis with invasion of central nervous system. It can imitate psychiatric disorders such as mood disorders, psychosis, and dementia.1 There are a few cases of neurosyphilis with dementia that were reported previously.24 Here, we report on a patient who was first diagnosed with frontotemporal dementia, but who was finally shown to have neurosyphilis.

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FIGURE 1. Hyperintense Signal Changes on Both Mesial Temporal Lobes in the Axial Section on MRI

FIGURE 2. Cerebral Atrophy, Triventricular Hydrocephalus, and Periventricular Lesion in the Axial Section on MRI
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References

Hutto  B:  Syphilis in clinical psychiatry: a review.  Psychosomatics 2001; 42:453–460
[CrossRef] | [PubMed]
 
Keskin  G;  Sunter  G;  Midi  I  et al:  Neurosyphilis as a cause of cognitive decline and psychiatric symptoms at younger age.  J Neuropsychiatry Clin Neurosci 2011; 23:E41–E42
[CrossRef] | [PubMed]
 
Mehrabian  S;  Raycheva  M;  Traykova  M  et al:  Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging.  BMC Neurol 2012; 12:96
[CrossRef] | [PubMed]
 
Brinar  VV;  Habek  M:  Dementia and white-matter demyelination in young patient with neurosyphilis.  Lancet 2006; 368:2258
[CrossRef] | [PubMed]
 
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