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Hippocampal and Subcortical Alterations of First-Episode, Medication-Naïve Major Depressive Disorder With Panic Disorder Patients
Chien-Han Lai, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:142-149. doi:10.1176/appi.neuropsych.12090230
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From the Dept. of Psychiatry, Cheng Hsin General Hospital, Taipei City, Taiwan, ROC, and the Dept. of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.

Send correspondence to Dr. Lai; e-mail: stephenlai99@gmail.com

Copyright © 2014 by the American Psychiatric Association

Received September 25, 2012; Revised January 04, 2013; Accepted January 14, 2013.

Abstract

The authors conducted a subcortical analysis of first-episode, medication-naïve patients with major depressive disorder comorbid with panic disorder. A sample of 15 patients were compared with 15 healthy controls to explore volumetric differences of subcortical regions and hippocampus, including the putamen and thalamus. The patient group had smaller volumes of left hippocampus, thalamus, and putamen. Subcortical and hippocampal volumes in the patient group showed significant negative correlations with symptom severity. Structural alterations of the putamen, hippocampus, and thalamus might represent the structural pathophysiology of major depressive disorder comorbid with panic disorder.

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FIGURE 1. FIRST Results of Significant Subcortical Structural Differences Between the Patient and the Healthy-Control Group

The subcortical structures include left hippocampus (upper left), right hippocampus (upper right), left putamen (middle left), right putamen (middle right), left thalamus (lower left), and right thalamus (lower right). The color and number (right color scale) represented the F test for group differences.

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TABLE 1.Demographic Data of Participants
Table Footer Note

Values are mean (SD).

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SD: standard deviation; F: female, M: male; QIDS-SR16: Quick Inventory for Depressive Symptoms, Self Rating Version; Ham-D: Hamilton Rating Scale for Depression; Ham-A: Hamilton Rating Scale for Anxiety; PDSS: Panic Disorder Severity Scale; NS: not significant.

Table Footer Note

*two-tailed p <0.05.

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TABLE 2.Volumetric Differences in Hippocampal and Subcortical Areas Between Patient and Control Group (Mann-Whitney U test correction)
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Values are mean (SD), unless otherwise indicated. Volumes and differences are in mm3.

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SD: standard deviation; df: 28 for all tests; CI: confidence interval; NS: not significant.

Table Footer Note

*mean two-tailed p <0.05.

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TABLE 3.Volumetric Differences in Hippocampal and Subcortical Areas (after scaling by total brain volume) Between Patient Group and Control Group (Mann-Whitney U test correction)
Table Footer Note

SD: standard deviation; df: degrees of freedom; CI: confidence interval; df: 28 for all tests.

Table Footer Note

*mean two-tailed p <0.05.

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References

MacQueen  GM;  Campbell  S;  McEwen  BS  et al:  Course of illness, hippocampal function, and hippocampal volume in major depression.  Proc Natl Acad Sci U S A 2003; 100:1387–1392
[CrossRef] | [PubMed]
 
Frodl  TS;  Koutsouleris  N;  Bottlender  R  et al:  Depression-related variation in brain morphology over 3 years: effects of stress? Arch Gen Psychiatry 2008; 65:1156–1165
[CrossRef] | [PubMed]
 
Saylam  C;  Uçerler  H;  Kitiş  O  et al:  Reduced hippocampal volume in drug-free depressed patients.  Surg Radiol Anat 2006; 28:82–87
[CrossRef] | [PubMed]
 
Frodl  T;  Jäger  M;  Smajstrlova  I  et al:  Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study.  J Psychiatry Neurosci 2008; 33:423–430
[PubMed]
 
Koolschijn  PC;  van Haren  NE;  Lensvelt-Mulders  GJ  et al:  Brain volume abnormalities in major depressive disorder: a meta-analysis of magnetic resonance imaging studies.  Hum Brain Mapp 2009; 30:3719–3735
[CrossRef] | [PubMed]
 
Videbech  P;  Ravnkilde  B:  Hippocampal volume and depression: a meta-analysis of MRI studies.  Am J Psychiatry 2004; 161:1957–1966
[CrossRef] | [PubMed]
 
Drevets  WC:  Neuroimaging studies of mood disorders.  Biol Psychiatry 2000; 48:813–829
[CrossRef] | [PubMed]
 
Sheline  YI:  3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity.  Biol Psychiatry 2000; 48:791–800
[CrossRef] | [PubMed]
 
Geuze  E;  Vermetten  E;  Bremner  JD:  MR-based in-vivo hippocampal volumetrics, 2: findings in neuropsychiatric disorders.  Mol Psychiatry 2005; 10:160–184
[CrossRef] | [PubMed]
 
Yoo  HK;  Kim  MJ;  Kim  SJ  et al:  Putaminal gray-matter volume decrease in panic disorder: an optimized voxel-based morphometry study.  Eur J Neurosci 2005; 22:2089–2094
[CrossRef] | [PubMed]
 
Asami  T;  Yamasue  H;  Hayano  F  et al:  Sexually dimorphic gray-matter volume reduction in patients with panic disorder.  Psychiatry Res 2009; 173:128–134
[CrossRef] | [PubMed]
 
Kessler  RC;  Stang  PE;  Wittchen  HU  et al:  Lifetime panic-depression comorbidity in the National Comorbidity Survey.  Arch Gen Psychiatry 1998; 55:801–808
[CrossRef] | [PubMed]
 
Roy-Byrne  PP;  Stang  P;  Wittchen  HU  et al:  Lifetime panic-depression comorbidity in the National Comorbidity Survey: association with symptoms, impairment, course, and help-seeking.  Br J Psychiatry 2000; 176:229–235
[CrossRef] | [PubMed]
 
Souery  D;  Oswald  P;  Massat  I  et al; Group for the Study of Resistant Depression:  Clinical factors associated with treatment resistance in major depressive disorder: results from a European multicenter study.  J Clin Psychiatry 2007; 68:1062–1070
[CrossRef] | [PubMed]
 
Szádóczky  E;  Vitrai  J;  Rihmer  Z  et al:  Suicide attempts in the Hungarian adult population: their relation with DIS/DSM-III-R affective and anxiety disorders.  Eur Psychiatry 2000; 15:343–347
[CrossRef] | [PubMed]
 
Maier  W;  Minges  J;  Lichtermann  D:  The familial relationship between panic disorder and unipolar depression.  J Psychiatr Res 1995; 29:375–388
[CrossRef] | [PubMed]
 
Mannuzza  S;  Chapman  TF;  Klein  DF  et al:  Familial transmission of panic disorder: effect of major depression comorbidity.  Anxiety 1994-1995; 1:180–185
[CrossRef]
 
de Jong  LW;  van der Hiele  K;  Veer  IM  et al:  Strongly reduced volumes of putamen and thalamus in Alzheimer’s disease: an MRI study.  Brain 2008; 131:3277–3285
[CrossRef] | [PubMed]
 
Lee  H;  Hoffman  C;  Kingsley  PB  et al:  Enhanced detection of diffusion reductions in Creutzfeldt-Jakob disease at a higher B factor.  AJNR Am J Neuroradiol 2010; 31:49–54
[CrossRef] | [PubMed]
 
Oldfield  RC:  The assessment and analysis of handedness: The Edinburgh Inventory.  Neuropsychologia 1971; 9:97–113
[CrossRef] | [PubMed]
 
Lai  CH;  Hsu  YY:  A subtle grey-matter increase in first-episode, drug-naive major depressive disorder with panic disorder after 6 weeks’ duloxetine therapy.  Int J Neuropsychopharmacol 2011; 14:225–235
[CrossRef] | [PubMed]
 
Lai  CH;  Hsu  YY;  Wu  YT:  First episode, drug-naïve major depressive disorder with panic disorder: gray-matter deficits in limbic and default network structures.  Eur Neuropsychopharmacol 2010; 20:676–682
[CrossRef] | [PubMed]
 
Parashos  IA;  Tupler  LA;  Blitchington  T  et al:  Magnetic-resonance morphometry in patients with major depression.  Psychiatry Res 1998; 84:7–15
[CrossRef] | [PubMed]
 
Li  CT;  Lin  CP;  Chou  KH  et al:  Structural and cognitive deficits in remitting and non-remitting recurrent depression: a voxel-based morphometric study.  Neuroimage 2010;50:347–356
[CrossRef] | [PubMed]
 
Vasic  N;  Walter  H;  Höse  A  et al:  Gray-matter reduction associated with psychopathology and cognitive dysfunction in unipolar depression: a voxel-based morphometry study.  J Affect Disord 2008; 109:107–116
[CrossRef] | [PubMed]
 
Bielau  H;  Trübner  K;  Krell  D  et al:  Volume deficits of subcortical nuclei in mood disorders: a postmortem study.  Eur Arch Psychiatry Clin Neurosci 2005; 255:401–412
[CrossRef] | [PubMed]
 
Young  KA;  Holcomb  LA;  Bonkale  WL  et al:  5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system.  Biol Psychiatry 2007; 61:813–818
[CrossRef] | [PubMed]
 
Kim  MJ;  Hamilton  JP;  Gotlib  IH:  Reduced caudate gray-matter volume in women with major depressive disorder.  Psychiatry Res 2008; 164:114–122
[CrossRef] | [PubMed]
 
Lacerda  AL;  Nicoletti  MA;  Brambilla  P  et al:  Anatomical MRI study of basal ganglia in major depressive disorder.  Psychiatry Res 2003; 124:129–140
[CrossRef] | [PubMed]
 
Matsuo  K;  Rosenberg  DR;  Easter  PC  et al:  Striatal volume abnormalities in treatment-naïve patients diagnosed with pediatric major depressive disorder.  J Child Adolesc Psychopharmacol 2008; 18:121–131
[CrossRef] | [PubMed]
 
Pizzagalli  DA;  Holmes  AJ;  Dillon  DG  et al:  Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder.  Am J Psychiatry 2009; 166:702–710
[CrossRef] | [PubMed]
 
Kronmüller  KT;  Pantel  J;  Götz  B  et al:  Life events and hippocampal volume in first-episode major depression.  J Affect Disord 2008; 110:241–247
[CrossRef] | [PubMed]
 
Zou  K;  Deng  W;  Li  T  et al:  Changes of brain morphometry in first-episode, drug-naïve, non-late-life adult patients with major depression: an optimized voxel-based morphometry study.  Biol Psychiatry 2010; 67:186–188
[CrossRef] | [PubMed]
 
Vythilingam  M;  Anderson  ER;  Goddard  A  et al:  Temporal lobe volume in panic disorder: a quantitative magnetic resonance imaging study.  Psychiatry Res 2000; 99:75–82
[CrossRef] | [PubMed]
 
Protopopescu  X;  Pan  H;  Tuescher  O  et al:  Increased brainstem volume in panic disorder: a voxel-based morphometric study.  Neuroreport 2006; 17:361–363
[CrossRef] | [PubMed]
 
Sobanski  T;  Wagner  G;  Peikert  G  et al  Temporal and right frontal lobe alterations in panic disorder: a quantitative volumetric and voxel-based morphometric MRI study.  Psychol Med 2010; 40:1879–1886
 
Kronmüller  KT;  Schröder  J;  Köhler  S  et al:  Hippocampal volume in first-episode and recurrent depression.  Psychiatry Res 2009; 174:62–66
[CrossRef] | [PubMed]
 
Frodl  T;  Meisenzahl  EM;  Zetzsche  T  et al:  Hippocampal changes in patients with a first episode of major depression.  Am J Psychiatry 2002; 159:1112–1118
[CrossRef] | [PubMed]
 
Patenaude  B;  Smith  SM;  Kennedy  DN  et al:  A Bayesian model of shape and appearance for subcortical brain segmentation.  Neuroimage 2011; 56:907–922
[CrossRef] | [PubMed]
 
Yun  S;  White  L:  MRI volumetric analysis techniques, including hippocampus extraction, based on data from the Honolulu Asia Aging Study (HAAS).  Ethn Dis 2010; 20(S1):104–106
 
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