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Letters   |    
Blonanserin Improved Dystonia Induced by Risperidone or Olanzapine in Two Patients With Schizophrenia
Manabu Takaki, M.D., Ph.D.; Yutaka Mizuki, M.D.; Tomoko Miki, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:E14. doi:10.1176/appi.neuropsych.13030069
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The authors report no financial relationships with commercial interests.

This study was partly supported by a grant from the Zikei Institute of Psychiatry.

Dept. of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama City, Japan

Send correspondence to Dr. Takaki; e-mail: manabuta@cc.okayama-u.ac.jp

Copyright © 2014 by the American Psychiatric Association

Extract

To the Editor: Blonanserin has strong dopamine 2 (D2) receptor, 5-hydroxytryptamine (5-HT)-2A receptor, D3 receptor blocking activity and weak 5HT-2C, D1, and α1 receptor blocking activities while being almost devoid of histamine H1 and muscarinic M1 blocking activity.1,2 Discontinuation of BNS for intolerability was the least frequent among atypical psychotics.3 We present two cases in which dystonia induced by risperidone or olanzapine was improved after switching to blonanserin.

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References

Deeks  ED;  Keating  GM:  Blonanserin: a review of its use in the management of schizophrenia.  CNS Drugs 2010; 24:65–84
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Yang  J;  Bahk  WM;  Cho  HS  et al:  Efficacy and tolerability of Blonanserin in the patients with schizophrenia: a randomized, double-blind, risperidone-compared trial.  Clin Neuropharmacol 2010; 33:169–175
[CrossRef] | [PubMed]
 
Takaki  M;  Okahisa  Y;  Kodama  M  et al:  Efficacy and tolerability of blonanserin in 48 patients with intractable schizophrenia.  Acta Neuropsychiatr 2012; 24:380–383
[CrossRef]
 
Kane  JM;  Leucht  S;  Carpenter  D  et al: Expert Consensus Panel for Optimizing Pharmacologic Treatment of Psychotic Disorders:  The expert consensus guideline series. Optimizing pharmacologic treatment of psychotic disorders. Introduction: methods, commentary, and summary.  J Clin Psychiatry 2003; 64(Suppl 12):5–19
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Joyce  JN;  Millan  MJ:  Dopamine D3 receptor antagonists as therapeutic agents.  Drug Discov Today 2005; 10:917–925
[CrossRef] | [PubMed]
 
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