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From Metabolism to Psychiatric Symptoms: Psychosis as a Manifestation of Acute Intermittent Porphyria
Olga Bautista, M.D.; José Camilo Vázquez-Caubet, M.D.; Eileen A. Zhivago, M.D; María Dolores Sáiz, M.D., Ph.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:E30. doi:10.1176/appi.neuropsych.13040083
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The authors report no financial relationships with commercial interests.

Hospital Clínico San Carlos, Madrid, Spain

Send correspondence to Dr. Bautista; e-mail: olgabautistagarrido@gmail.com

Copyright © 2014 by the American Psychiatric Association


To the Editor: Acute intermittent porphyria (AIP) is the most common among acute porphyrias (1 in 50,000 people, in Northern Europe 1–2 in 15,000 people). This is an autosomal dominant inheritance, which affects porphobilinogen deaminase producing hepatic accumulation and urinary-fecal presence of porphobilinogen and delta-aminolevulinic acid.1

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Asociación española de Porfiria (AEP). Tipos de porfirias. http://www.porfiria.org/las-porfirias/tipos. Accessed February 20, 2011
Ellencweig  N;  Schoenfeld  N;  Zemishlany  Z:  Acute intermittent porphyria: psychosis as the only clinical manifestation.  Isr J Psychiatry Relat Sci 2006; 43:52–56
González-Arriaza  HL;  Bostwick  JM:  Acute porphyrias: a case report and review.  Am J Psychiatry 2003; 160:450–459
[CrossRef] | [PubMed]
Poblete-Gutiérrez  P;  Wiederholt  T;  Merk  HF  et al:  The porphyrias: clinical presentation, diagnosis and treatment.  Eur J Dermatol 2006; 16:230–240
Braunwald  E;  Fauci  A;  Kasper  D  et al: (ed):  Harrison's Principles of Internal Medicine , 15th ed.  New York, New York,  McGraw Hill, 2001
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