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GAD65 Autoantibodies in Kleine-Levin Syndrome
Ujjwal K. Rout, Ph.D.; Meeta Shah Michener, M.D.; Dirk M. Dhossche, M.D., Ph.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:E49-E51. doi:10.1176/appi.neuropsych.13050110
View Author and Article Information

The authors report no financial relationships with commercial interests.

This work was supported by an Intramural Grant, UMMC to Ujjwal K. Rout and Dirk M. Dhossche.

Dept. of Surgery, Physiology and Biophysics, University of Mississippi Medical Center (UMMC), Jackson, Miss.

Dept. of Psychiatry and Human Behavior, University of Mississippi Medical Center (UMMC), Jackson, Miss.

Send correspondence to Dr. Rout; e-mail- ujjwalrout11@gmail.com

Copyright © 2014 by the American Psychiatric Association


To the Editor: Kleine-Levin syndrome (KLS), or Sleeping Beauty syndrome, is a rare disorder that mainly affects adolescents and is characterized by recurring episodes of severe hypersomnia, cognitive impairment, apathy, derealization, and psychiatric and behavioral disturbances.1

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FIGURE 1. Total IgG (A) and Autoantibodies Against GAD65 Isofom (B) in Control Subjects (1 and 2) and the Patient With Kleine-Levin Syndrome


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GAD65 autoantibodies in Kleine-Levin syndrome. J Neuropsychiatry Clin Neurosci 2014;26(2):E49-51.