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Sertraline-Induced Acneiform Eruption
Siddhartha Sinha, M.B.B.S., D.P.M.; Suma Udupa, M.B.B.S., D.P.M.; Rajeshkrishna P. Bhandary, M.B.B.S., M.D.; Samir Kumar Praharaj, M.B.B.S., M.D., D.P.M.; Ravindra N. Munoli, M.B.B.S., M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:E56-E57. doi:10.1176/appi.neuropsych.13050113
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The authors report no financial relationships with commercial interests.

Dept. of Psychiatry, Kasturba Medical College, Manipal, Karnataka, India

Send correspondence to Dr. Praharaj; e-mail: samirpsyche@yahoo.co.in

Copyright © 2014 by the American Psychiatric Association


To the Editor: Sertraline is a specific serotonin reuptake inhibitor (SSRI) antidepressant, which is uncommonly associated with adverse cutaneous drug reactions such as rash, pruritus, dermatitis, purpura, urticaria, and rarely, Steven-Johnson syndrome.1 The summary of product characteristics (SPC) for sertraline shows acneiform eruptions is associated infrequently with sertraline.2 A PUBMED search did not reveal any report of such association in English literature. We report a case of paranoid schizophrenia patient who developed acneiform lesions after treatment with sertraline 50 mg/day for depressive symptoms, and it subsided within 5 days of discontinuation of the drug.

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FIGURE 1. Papulopustular Eruptions Over Face


Krasowska  D;  Szymanek  M;  Schwartz  RA  et al:  Cutaneous effects of the most commonly used antidepressant medication, the selective serotonin reuptake inhibitors.  J Am Acad Dermatol 2007; 56:848–853
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Summary of product characteristics. Zoloft: prescribing information. Available at: http://labeling.pfizer.com/ShowLabeling.aspx?id=517. Accessed May 22, 2013
Naranjo  CA;  Busto  U;  Sellers  EM  et al:  A method for estimating the probability of adverse drug reactions.  Clin Pharmacol Ther 1981; 30:239–245
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Du-Thanh  A;  Kluger  N;  Bensalleh  H  et al:  Drug-induced acneiform eruption.  Am J Clin Dermatol 2011; 12:233–245
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Momin  SB;  Peterson  A;  Del Rosso  JQ:  A status report on drug-associated acne and acneiform eruptions.  J Drugs Dermatol 2010; 9:627–636
Khanna  S;  Chirinos  RE;  Venna  S:  Escitalopram oxalate (Lexapro)-induced acneiform eruption.  J Am Acad Dermatol 2012; 67:e261–e263
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Cederberg  J;  Knight  S;  Svenson  S  et al:  Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report.  BMC Psychiatry 2004; 4:36
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