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REGULAR ARTICLES   |    
Cognitive and Other Predictors of Change in Quality of Life One-Year After Treatment for Chronic Myelogenous Leukemia or Myelodysplastic Syndrome
Grace Chang, M.D., M.P.H.; Mary-Ellen Meadows, Ph.D.; Jennifer A. Smallwood, M.P.H.; Joseph H. Antin, M.D.; E. John Orav, Ph.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;:. doi:10.1176/appi.neuropsych.12070177
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From the Harvard Medical School, Boston, MA (GC, MM, JHA, EJO); Brigham and Women’s Hospital, Boston, MA (GC, MM, JAS, JHA, EJO); VA Boston Healthcare System, Brockton, MA (GC);and Dana Farber Cancer Institute, Boston, MA (JHA).

Send correspondence to Dr. Chang; e-mail: grace.chang2@va.gov

Copyright © 2014 by the American Psychiatric Association

Received July 18, 2012; Revised February 13, 2013; Revised March 20, 2013; Revised May 02, 2013; Accepted May 03, 2013.

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Abstract

The role of cognitive function in quality of life is important among the growing numbers of survivors after cancer treatment. The authors conducted a prospective cohort study of 106 adults evaluated 5.6 months (median) after diagnosis and 77 of 83 (93%) survivors 12 months later with neuropsychological assessments yielding information about simple reaction time to stimuli and other aspects of cognitive function and with two quality of life measures. The two most consistent predictors of change in quality of life were baseline quality of life ratings and simple reaction time. This novel finding about simple reaction time warrants further confirmation.

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