0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

REGULAR ARTICLES   |    
Cognitive and Other Predictors of Change in Quality of Life One Year After Treatment for Chronic Myelogenous Leukemia or Myelodysplastic Syndrome
Grace Chang, M.D., M.P.H.; Mary-Ellen Meadows, Ph.D.; Jennifer A. Smallwood, M.P.H.; Joseph H. Antin, M.D.; E. John Orav, Ph.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:249-257. doi:10.1176/appi.neuropsych.12070177
View Author and Article Information

The authors report no financial relationships with commercial interests.

This study was funded by grants from the American Cancer Society (RSG-01-246-01, GC) and the National Institute on Alcohol Abuse and Alcoholism (K24AA00289, GC). Study sponsors had no involvement in study design; data acquisition, analysis, or interpretation; writing or submission of the manuscript.

From the Harvard Medical School, Boston, MA (GC, MM, JHA, EJO); Brigham and Women’s Hospital, Boston, MA (GC, MM, JAS, JHA, EJO); VA Boston Healthcare System, Brockton, MA (GC); and Dana Farber Cancer Institute, Boston, MA (JHA).

Send correspondence to Dr. Chang; e-mail: grace.chang2@va.gov

Copyright © 2014 by the American Psychiatric Association

Received July 18, 2012; Revised February 13, 2013; Revised March 20, 2013; Revised May 02, 2013; Accepted May 03, 2013.

Abstract

The role of cognitive function in quality of life is important among the growing numbers of survivors after cancer treatment. The authors conducted a prospective cohort study of 106 adults evaluated 5.6 months (median) after diagnosis and 77 of 83 (93%) survivors 12 months later with neuropsychological assessments yielding information about simple reaction time to stimuli and other aspects of cognitive function and with two quality of life measures. The two most consistent predictors of change in quality of life were baseline quality of life ratings and simple reaction time. This novel finding about simple reaction time warrants further confirmation.

Abstract Teaser
Figures in this Article

Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
 
Username
Password
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

Anchor for Jump
TABLE 1.Baseline Demographic and Clinical Characteristics of the Study Sample
Table Footer Note

aResults for the Cognitive Test Domains (except for Reaction Time) are presented as mean z scores with (SD).

Table Footer Note

bBased on N=72.

Anchor for Jump
TABLE 2.Univariate Models for Predictors of Change in Quality of Life Measures between Enrollment and 12 Months
Table Footer Note

aModels adjusted for initial FLIC.

Table Footer Note

bModels adjusted for initial MCS.

Table Footer Note

cModels adjusted for initial PCS.

Anchor for Jump
TABLE 3.Multivariate Models of Predictors of Change in Quality of Life Measures between Enrollment and 12 Months
Table Footer Note

*All Models adjusted for diagnosis and treatment, regardless of significance in univariate tests

+

References

Centers for Disease Control and Prevention (CDC):  Cancer survivors—United States, 2007.  MMWR Morb Mortal Wkly Rep 2011; 60:269–272
[PubMed]
 
Wefel  JS;  Witgert  ME;  Meyers  CA:  Neuropsychological sequelae of non-central nervous system cancer and cancer therapy.  Neuropsychol Rev 2008; 18:121–131
[CrossRef] | [PubMed]
 
Kiessling  A;  Henriksson  P:  Perceived cognitive function is a major determinant of health related quality of life in a non-selected population of patients with coronary artery disease—a principal components analysis.  Qual Life Res 2004; 13:1621–1631
[CrossRef] | [PubMed]
 
Phillips-Bute  B;  Mathew  JP;  Blumenthal  JA  et al:  Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery.  Psychosom Med 2006; 68:369–375
[CrossRef] | [PubMed]
 
Poppelreuter  M;  Weis  J;  Külz  AK  et al:  Cognitive dysfunction and subjective complaints of cancer patients. a cross-sectional study in a cancer rehabilitation centre.  Eur J Cancer 2004; 40:43–49
[CrossRef] | [PubMed]
 
Nail  LM:  Cognitive changes in cancer survivors. Cancer and cancer treatment often cause cognitive deficits, but no guidelines exist for screening or treatment.  Am J Nurs 2006; 106(Suppl):48–54
[CrossRef] | [PubMed]
 
Vardy  J;  Rourke  S;  Tannock  IF:  Evaluation of cognitive function associated with chemotherapy: a review of published studies and recommendations for future research.  J Clin Oncol 2007; 25:2455–2463
[CrossRef] | [PubMed]
 
Cull  A;  Hay  C;  Love  SB  et al:  What do cancer patients mean when they complain of concentration and memory problems? Br J Cancer 1996; 74:1674–1679
[CrossRef] | [PubMed]
 
Lai  JS;  Butt  Z;  Wagner  L  et al:  Evaluating the dimensionality of perceived cognitive function.  J Pain Symptom Manage 2009; 37:982–995
[CrossRef] | [PubMed]
 
Harder  H;  Cornelissen  JJ;  Van Gool  AR  et al:  Cognitive functioning and quality of life in long-term adult survivors of bone marrow transplantation.  Cancer 2002; 95:183–192
[CrossRef] | [PubMed]
 
Deary  IJ;  Der  G:  Reaction time explains IQ’s association with death.  Psychol Sci 2005; 16:64–69
[CrossRef] | [PubMed]
 
Ajtay  Z;  Kellényi  L;  Hejjel  L  et al:  Simple and choice reaction times are prolonged following extracorporeal circulation: a potential method for the assessment of acute neurocognitive deficit.  Med Sci Monit 2009; 15:CR470–CR476
[PubMed]
 
Juergens  A;  Pels  H;  Rogowski  S  et al:  Long-term survival with favorable cognitive outcome after chemotherapy in primary central nervous system lymphoma.  Ann Neurol 2010; 67:182–189
[CrossRef] | [PubMed]
 
Klein  M;  Taphoorn  MJB;  Heimans  JJ  et al:  Neurobehavioral status and health-related quality of life in newly diagnosed high-grade glioma patients.  J Clin Oncol 2001; 19:4037–4047
[PubMed]
 
Quintás-Cardama  A;  Cortes  JE:  Chronic myeloid leukemia: diagnosis and treatment.  Mayo Clin Proc 2006; 81:973–988
[CrossRef] | [PubMed]
 
Steensma  DP;  Bennett  JM:  The myelodysplastic syndromes: diagnosis and treatment.  Mayo Clin Proc 2006; 81:104–130
[CrossRef] | [PubMed]
 
Caro  JJ;  Salas  M;  Ward  A  et al:  Anemia as an independent prognostic factor for survival in patients with cancer: a systemic, quantitative review.  Cancer 2001; 91:2214–2221
[CrossRef] | [PubMed]
 
Heinonen  H;  Volin  L;  Uutela  A  et al:  Quality of life and factors related to perceived satisfaction with quality of life after allogeneic bone marrow transplantation.  Ann Hematol 2001; 80:137–143
[CrossRef] | [PubMed]
 
Heinonen  H;  Volin  L;  Uutela  A  et al:  Gender-associated differences in the quality of life after allogeneic BMT.  Bone Marrow Transplant 2001; 28:503–509
[CrossRef] | [PubMed]
 
Chiodi  S;  Spinelli  S;  Ravera  G  et al:  Quality of life in 244 recipients of allogeneic bone marrow transplantation.  Br J Haematol 2000; 110:614–619
[CrossRef] | [PubMed]
 
Chang  G;  Meadows  ME;  Orav  EJ  et al:  Mental status changes after hematopoietic stem cell transplantation.  Cancer 2009; 115:4625–4635
[CrossRef] | [PubMed]
 
First  MB;  Spitzer  RL;  Gibbon  M  et al:  Structured clinical interview for axis I DSM-IV disorders. Patient edition (SCID-I/P, Version 2.0) .  New York,  Biometrics Research Department, New York State Psychiatric Institute, 1994
 
McHorney  CA;  Ware  JE  Jr;  Raczek  AE:  The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs.  Med Care 1993; 31:247–263
[CrossRef] | [PubMed]
 
Schipper  H;  Clinch  J;  McMurray  A  et al:  Measuring the quality of life of cancer patients: the Functional Living Index-Cancer: development and validation.  J Clin Oncol 1984; 2:472–483
[PubMed]
 
Cella  DF;  Jacobsen  PB;  Orav  EJ  et al:  A brief POMS measure of distress for cancer patients.  J Chronic Dis 1987; 40:939–942
[CrossRef] | [PubMed]
 
Ware  JE;  Kosinski  M:  SF-36 physical and mental health summary scales: A manual for users of version 1 , 2nd ed.  Lincoln, RI,  Quality Metric Incorporated, 2001
 
Andrykowski  MA;  Schmitt  FA;  Gregg  ME  et al:  Neuropsychologic impairment in adult bone marrow transplant candidates.  Cancer 1992; 70:2288–2297
[CrossRef] | [PubMed]
 
Buschke  H;  Fuld  PA:  Evaluating storage, retention, and retrieval in disordered memory and learning.  Neurology 1974; 24:1019–1025
[CrossRef] | [PubMed]
 
Masur  DM;  Fuld  PA;  Blau  AD  et al:  Distinguishing normal and demented elderly with the selective reminding test.  J Clin Exp Neuropsychol 1989; 11:615–630
[CrossRef] | [PubMed]
 
Wechsler  D:  Wechsler Adult Intelligence Scale , 3rd ed.  San Antonio, TX,  Psychological Corporation, 1997
 
Reitan  RM:  The relation of the trail making test to organic brain damage.  J Consult Psychol 1955; 19:393–394
[CrossRef] | [PubMed]
 
Benton  AL;  Hamsher Kde  S:  Multilingual Aphasia Examination .  Iowa City, IA,  AJA Associates, 1989
 
Golden  CJ;  Freshwater  SM:  Stroop color and word test .  Los Angeles, CA,  Western Psychological Services, 1998
 
 Grooved Pegboard .  Lutz, FL,  Psychological Assessment Resources, Inc., 2000
 
Lezak  MD;  Howieson  DB;  Loring  DW:  Neuropsychological Assessment , 4th ed.  New York,  Oxford University Press, 2004
 
Cohen  JD;  MacWhinney  B;  Flatt  M  et al:  PsyScope: A new graphic interactive environment for designing psychology experiments.  Behav Res Methods Instrum Comput 1993; 25:257–271
[CrossRef]
 
Strauss  E;  Sherman  EMS;  Spree  O:  A compendium of neuropsychological tests: administration, norms, commentary , 3rd ed.  New York,  Oxford University Press, 2006
 
Ahles  TA;  Saykin  AJ;  McDonald  BC  et al:  Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve.  J Clin Oncol 2010; 28:4434–4440
[CrossRef] | [PubMed]
 
Wingard  JR;  Huang  IC;  Sobocinski  KA  et al:  Factors associated with self-reported physical and mental health after hematopoietic cell transplantation.  Biol Blood Marrow Transplant 2010; 16:1682–1692
[CrossRef] | [PubMed]
 
Kuenstner  S;  Langelotz  C;  Budach  V  et al:  The comparability of quality of life scores. a multitrait multimethod analysis of the EORTC QLQ-C30, SF-36 and FLIC questionnaires.  Eur J Cancer 2002; 38:339–348
[CrossRef] | [PubMed]
 
Pedersen  G;  Karterud  S:  Is SCL-90R helpful for the clinician in assessing DSM-IV symptom disorders? Acta Psychiatr Scand 2004; 110:215–224
[CrossRef] | [PubMed]
 
References Container
+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Related Content
Articles
Books
Textbook of Traumatic Brain Injury, 2nd Edition > Chapter 39.  >
Textbook of Traumatic Brain Injury, 2nd Edition > Chapter 39.  >
The American Psychiatric Publishing Textbook of Geriatric Psychiatry, 4th Edition > Chapter 3.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 38.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 38.  >
Topic Collections
Psychiatric News