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REGULAR ARTICLES   |    
Cognitive Function in Patients With Alcoholic and Nonalcoholic Chronic Liver Disease
Carlos Brodersen, M.D.; Eduardo Koen, M.D.; Alicia Ponte, M.D.; Silvina Sánchez, M.D.; Eduardo Segal, M.D.; Alberto Chiapella, M.D.; Maria Fernández; Maria Torres, M.D.; Valeria Tripodi, Dr. in Biochemistry; Abraham Lemberg, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:241-248. doi:10.1176/appi.neuropsych.12040091
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From the Gastroenterology Division, Hospital Durand, Buenos Aires, Argentina (CB); the Psychology Service, Hospital Durand, Buenos Aires, Argentina (EK, AP, E Sánchez, E Segal, AC); the Dept. of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (MF, MT, AL); the Dept. of Analytical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (VT); and the Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Buenos Aires, Argentina (VT).

Send correspondence to Abraham Lemberg, M.D.; e-mail: alemberg@ffyb.uba.ar

Copyright © 2014 by the American Psychiatric Association

Received April 13, 2012; Revised March 25, 2013; Revised April 8, 2013; Revised May 2, 2013; Accepted May 03, 2013.

Abstract

The aim of the present study was to characterize the neurophysiological profile of cognitive impairment associated with patients with chronic alcoholic and nonalcoholic liver disease. The authors evaluated 43 patients with cirrhotic liver disease: 19 patients with chronic alcohol ingestion and 24 nonalcoholic patients who had been infected with hepatitis B or C virus. Eleven healthy subjects were included as control subjects. A battery of 12 psychological tests was used to investigate cognitive deficits in the patients with chronic liver disease. It was observed that alcoholic patients with chronic liver disease showed a more important cognitive deterioration than those affected by hepatitis B or C virus.

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FIGURE 1. WAIS-Perceptual Speed Subtest of Conceptual Similarity Ability

FIGURE 2. Figural Visual Scanning

FIGURE 3. Reitan’s Test
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