To the Editor: A case of a cavum septi pellucidi (CSP) and cavum vergae (CV) discovered incidentally in a 65-year-old woman with history of bipolar disorder with suicidal ideations is reported. The decedent died as a result of acute anoxic-ischemic encephalopathy of unknown etiology (patient was found unresponsive on the street). A head CT scan performed on admission to the emergency room showed a cystic space within the septum pellucidum with significant caudal extension consistent with a CSP/CV (Figure 1A). The two cava were not separated (Figure 1A). The antero-posterior length measured on CT was 5.7 cm. A follow-up head CT performed 2 days after admission demonstrated, besides the cava (Figures 1B and 1C), hypodensities in the thalamic and lentiform nuclei bilaterally consistent with hypoxic/ischemic injury (Figure 1C). Neuropathological evaluation at autopsy revealed a large CSP (Figures 2A-2C and Figures 3A) extending caudally to become CSP/CV (Figures 2D, 3B, 4A, and 4B). There was moderate dilatation of the lateral ventricles but no evidence of fenestrations in the septal leaves, pointing against a communication between the septal cavum and the lateral ventricles (Figure 3A).