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Letters   |    
Seizure With Sertraline: Is There a Risk?
Sukanto Sarkar, M.B.B.S., M.D., D.P.M.; Samyuktha Gangadhar, M.B.B.S.; Eswaran Subramaniam, M.B.B.S., M.D., D.P.M.; Samir Kumar Praharaj, M.B.B.S., M.D., D.P.M.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:E27-E28. doi:10.1176/appi.neuropsych.13070146
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The authors report no financial relationships with commercial interests.

Dept. of Psychiatry, Mahatma Gandhi Medical College and Research Institute, Puducherry, India

Dept. of Psychiatry, Kasturba Medical College, Manipal, Karnataka, India

Send correspondence to Dr. Praharaj; e-mail: samirpsyche@yahoo.co.in

Copyright © 2014 by the American Psychiatric Association


To the Editor: Seizures are serious adverse effects of some antidepressant drugs, and a better understanding of drug-related seizure risk, its predictors, and possible neuroanatomical basis might help to reduce this adverse event. Among the various antidepressants, selective serotonin reuptake inhibitors (SSRIs) are believed to have a lower seizure risk.1 However, various types of seizures are reported with the use of sertraline, particularly with a higher dose, including generalized seizures,2 partial seizures,3 and myoclonic seizures.4 Also, combining sertraline with other drugs such as clozapine and methylphenidate has been reported to precipitate seizures.3,5 We report a young woman who developed both myoclonic jerks and generalized seizure with sertraline.

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