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Divalproex Sodium and Quetiapine Treatment of a Pedophile With Bipolar Spectrum Disorder
Sheng-Chiang Wang; Yu-Chen Kao, M.D., M.Sc.; Yia-Ping Liu, M.D., Ph.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:E47-E48. doi:10.1176/appi.neuropsych.13080189
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The authors report no financial relationships with commercial interests.

Dept. of Psychiatry, Tri-Service General Hospital Songshan Branch, Taiwan, R.O.C

Dept. of Physiology and Biophysics, National Defense Medical Center, Taiwan, R.O.C

Send correspondence to Dr. Liu; e-mail address: yiapine@ms75.hinet.net

Copyright © 2014 American Psychiatric Association


To the Editor: Pedophilic disorder is a psychiatric disorder diagnosed in adults or adolescents, 16 years of age or older, having intense sexual urges and behaviors focused on sexual activity with prepubescent children at least 5 years younger. It leads to distress or interpersonal difficulty. Psychiatric comorbidity rates in pedophilia are high and require careful consideration during evaluation and drug treatment. Almost 60%‒70% of reported patients with pedophilia had a history of mood and anxiety disorders.1 Currently, there is no effective way to cure pedophilia; however, antiandrogen drugs and gonadotropin-releasing hormone analogs are used to reduce libido in an attempt to reduce or prevent pedophilic behaviors or child abuse.2 Here, we report a case of a male patient with pedophilia and bipolar spectrum disorder who responded to combination treatment with divalproex and quetiapine.

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Kafka  M:  Axis I psychiatric disorders, paraphilic sexual offending and implications for pharmacological treatment.  Isr J Psychiatry Relat Sci 2012; 49:255–261
Schiffer  B;  Peschel  T;  Paul  T  et al:  Structural brain abnormalities in the frontostriatal system and cerebellum in pedophilia.  J Psychiatr Res 2007; 41:753–762
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Comings  DE;  Blum  K:  Reward deficiency syndrome: genetic aspects of behavioral disorders.  Prog Brain Res 2000; 126:325–341
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