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Letters   |    
Aripiprazole as Monotherapy at Bedtime Was Effective for Treatment of Two Cases of Obsessive-Compulsive Disorder and Insomnia
Manabu Takaki, M.D., Ph.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:E64. doi:10.1176/appi.neuropsych.13100245
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Dept. of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan

Correspondence: Manabu Takaki, M.D., Ph.D.; e-mail: manabuta@cc.okayama-u.ac.jp

Copyright © 2014 by the American Psychiatric Association

Extract

To the Editor: The augmentation of selective reuptake inhibitors (SSRIs) with aripiprazole (APZ) is reported to be effective for treatment-resistant obsessive-compulsive disorder (OCD). Conversely, there is only one report of APZ as monotherapy for treatment of OCD.1 The authors effectively treated two cases of treatment-resistant OCD with APZ as monotherapy at bedtime. Although APZ is reported to induce insomnia more frequently than somnolence, in our cases, APZ taken in the morning induced sleepiness in the daytime and taken at bedtime ameliorated the insomnia induced by OCD. Depending on sleepiness, changing the administration time of APZ induces a better outcome of OCD.

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References

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Shapiro  DA;  Renock  S;  Arrington  E  et al:  Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.  Neuropsychopharmacology 2003; 28:1400–1411
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