Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Letters   |    
Aripiprazole as Monotherapy at Bedtime Was Effective for Treatment of Two Cases of Obsessive-Compulsive Disorder and Insomnia
Manabu Takaki, M.D., Ph.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:E64. doi:10.1176/appi.neuropsych.13100245
View Author and Article Information

Dept. of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan

Correspondence: Manabu Takaki, M.D., Ph.D.; e-mail: manabuta@cc.okayama-u.ac.jp

Copyright © 2014 by the American Psychiatric Association


To the Editor: The augmentation of selective reuptake inhibitors (SSRIs) with aripiprazole (APZ) is reported to be effective for treatment-resistant obsessive-compulsive disorder (OCD). Conversely, there is only one report of APZ as monotherapy for treatment of OCD.1 The authors effectively treated two cases of treatment-resistant OCD with APZ as monotherapy at bedtime. Although APZ is reported to induce insomnia more frequently than somnolence, in our cases, APZ taken in the morning induced sleepiness in the daytime and taken at bedtime ameliorated the insomnia induced by OCD. Depending on sleepiness, changing the administration time of APZ induces a better outcome of OCD.

Figures in this Article

First Page Preview

View Large
First page PDF preview
Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).



Connor  KM;  Payne  VM;  Gadde  KM  et al:  The use of aripiprazole in obsessive-compulsive disorder: preliminary observations in 8 patients.  J Clin Psychiatry 2005; 66:49–51
[CrossRef] | [PubMed]
Stip  E;  Tourjman  V:  Aripiprazole in schizophrenia and schizoaffective disorder: A review.  Clin Ther 2010; 32(Suppl 1):S3–S20
[CrossRef] | [PubMed]
Sarkar  R;  Klein  J;  Kruger  S:  Aripiprazole augmentation in treatmentrefractory obsessive-compulsive disorder.  Psychopharmacology 2008; 197:687–688
[CrossRef] | [PubMed]
Murotani  T;  Ishizuka  T;  Isogawa  Y  et al:  Possible involvement of serotonin 5-HT2 receptor in the regulation of feeding behavior through the histaminergic system.  Neuropharmacology 2011; 61:228–233
[CrossRef] | [PubMed]
Shapiro  DA;  Renock  S;  Arrington  E  et al:  Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.  Neuropsychopharmacology 2003; 28:1400–1411
[CrossRef] | [PubMed]
References Container

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe

Related Content
Textbook of Traumatic Brain Injury, 2nd Edition > Chapter 35.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 9.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 12.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 1.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 54.  >
Topic Collections
Psychiatric News
Read more at Psychiatric News >>
APA Guidelines