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High Prevalence of Antineuronal Antibodies in Tunisian Psychiatric Inpatients
Lilia Laadhar, M.D.; Oussama Sidhom, M.D.; Mondher Zitouni, M.D.; Nadia Sassi, Ph.D.; Wafa Abdelghaffar, M.D.; Houria Lahmar; Maryam Kallel-Sellami, M.D.; Zouhaier El Hechmi, M.D.; Sondes Makni, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;:. doi:10.1176/appi.neuropsych.13070153
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From the Dept. of Immunology, Al Rabta Hospital, Tunis, Tunisia (LL, NS, MZ, HL, MKS, SM); and Research Unit 03/04 “Schizophrenias,” Dept. of Psychiatry F, Al Razi Mental Health Hospital, Mannouba, Tunisia (OS, WA, ZEH).

Send correspondence to Laadhar Lilia, M.D.; e-mail: lilia_laadhar@yahoo.com

Copyright © 2014 by the American Psychiatric Association

Received July 09, 2013; Revised October 27, 2013; Accepted October 30, 2013.

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Abstract

The authors aimed to determine the prevalence of antineuronal antibodies in 103 psychiatric inpatients and 41 control subjects with no history of malignancies or neurological disorders. All sera were tested by indirect immunofluorescence and positive sera by immunoblot. Using immunofluorescence, antineuronal nuclear autoantibodies were detected in 20 patients and none of the control subjects, and antibodies reacted with the cytoplasm of Purkinje cells in six patients and two control subjects. The immunoblot confirmed well-characterized antineuronal antibodies only in five patients: two had anti-Ri and three had anti-Yo antibodies. After a follow-up of 5 years, none of these patients developed neurological disorder or malignancy.

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High Prevalence of Antineuronal Antibodies in Tunisian Psychiatric Inpatients. J Neuropsychiatry Clin Neurosci Published online Aug 8, 2014.;