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The Journal of Neuropsychiatry and Clinical Neurosciences, VOL. 1, No. 3

Article | August 01, 1989

Oxiracetam in the treatment of multi-infarct dementia and primary degenerative dementia

The Journal of Neuropsychiatry and Clinical Neurosciences 1989;1:249-252.

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Abstract

Oxiracetam is a recently synthesized nootropic that was tested as a potential treatment for cognitive decline in patients with multi- infarct dementia (MID) and primary degenerative dementia (PDD). Subjects were 34 MID patients and 39 PDD patients who met entrance criteria for the study. A repeated measures ANOVA showed significant improvement in both patients with MID and patients with PDD for word fluency. The total score on the Relatives' Assessment of Global Symptomatology-Elderly showed significant improvement for patients with PDD. The average score on the Instrumental Activities of Daily Living Scale, however, showed a significant decline for patients with PDD.

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