A 24-year-old woman who was premorbidly well-adjusted presented with an insidious-onset illness of 3 months' duration, with symptoms of catatonic schizophrenia. Her blood count, blood biochemistry, serum electrolytes, liver function tests, renal function test, chest X-ray (PA view), computerized tomography of the brain, and ECG did not reveal any abnormality. She was initially treated with ECT and tablet risperidone. She developed severe extrapyramidal side effects with risperidone and had to be shifted to quetiapine, which was gradually increased to 250 mg/day. With quetiapine and ECT, she showed significant improvement in symptoms. We explained to the patient and her husband about the contraceptive measures to be taken while she was on quetiapine. When on quetiapine for about 6 months, the patient conceived for the first time. Throughout the pregnancy, patient received quetiapine 250 mg/day, along with folic acid and iron supplementation. She was monitored closely and underwent regular ultrasonography. At full term, she gave birth to a healthy female child weighing 2.5 kg. The patient nursed the child during the postpartum period without any complications. She conceived again after about a year and again continued taking quetiapine 250 mg/day throughout the pregnancy. As in the previous pregnancy, the patient was closely monitored and she again delivered a healthy female child, weighing 2.4 kg, and continued breast-feeding for 6 months. Both the daughters were healthy, the first one about 2 years old and the second one about 9 months at the last assessment.