summarizes characteristics of the study population (N=301). There was an even cerebral distribution of single site tumors. Ninety-four (31%) individuals had bilateral tumors. Depression was the most common premorbid psychiatric disorder (n=18, 6%) followed by substance abuse (n=17, 6%) and anxiety disorders (n=16, 5%). Comorbid depression was diagnosed in 45 individuals (15%), 35 individuals had anxiety disorders (12%), and 13 patients had both disorders following the diagnosis of a brain tumor (4%). Thirty-four depressed patients (75%) were prescribed antidepressants, and 12 were seen by a psychiatrist at some point during their illness (27%). Depression was reported as frequently in males (n=21, 47%) as in females (n=24, 53%), but diagnoses of anxiety were more prevalent in females (n=26, 74%, p=0.01). Race, marital status, tumor type, location, and size were not found to be predictive of either disorder. Premorbid depression (n=18, 40%, p<0.001) and anxiety (n=16, 46%, p<0.001) were found to be highly predictive of future psychiatric illness in the setting of brain tumors using bivariate analyses. Survival times varied for patients with depression (11 months), anxiety (7 months), both disorders (3.5 months), and neither disorder (9 months), but were not statistically significant (p=0.69). Thirty patients with depression (67%, p=0.067) were given whole brain radiation treatments while 22 individuals with anxiety (63%) received radiation therapy (p=0.058). Eight patients with both disorders (62%) underwent whole brain radiation treatment.