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White-Matter Connectivity and Methylphenidate-Induced Changes in Attentional Performance According to α2A-Adrenergic Receptor Gene Polymorphisms in Korean Children With Attention-Deficit Hyperactivity Disorder
Subin Park, M.D., Ph.D.; Soon-Beom Hong, M.D., Ph.D.; Jae-Won Kim, M.D., Ph.D.; Young-Hui Yang, M.D.; Min-Hyeon Park, M.D.; Boong-Nyun Kim, M.D., Ph.D.; Min-Sup Shin, Ph.D.; Hee-Jeong Yoo, M.D., Ph.D.; Soo-Churl Cho, M.D., Ph.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:222-228. doi:10.1176/appi.neuropsych.12050121
View Author and Article Information

Please note that authors SB and S-BH contributed equally to this article.

This study was funded by the Health & Medical Technology R&D program A080054, Ministry of Health and Welfare, Republic of Korea.

From the Div. of Child and Adolescent Psychiatry, Dept. of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea (SP, S-BH, J-WK, M-HP, B-NK, M-SS, S-CC); Dept. of Psychiatry, Pusan National University YangSan Children's Hospital, Pusan, Republic of Korea (Y-HY); Dept. of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (H-JY).

Correspondence: Dr. Soo-Churl Cho; e-mail: soochurl@snu.ac.kr

Copyright © 2013 American Psychiatric Association

Received May 17, 2012; Revised August 07, 2012; Accepted August 11, 2012.

Abstract

The authors examined the association between the MspI C/G and DraI C/T genotypes of the α2A-adrenergic receptor gene and white-matter connectivity and attentional performance before and after medication in 53 children with attention-deficit hyperactivity disorder. Subjects who carried the T allele at the DraI polymorphism showed fewer changes in the mean commission error scores after 8 weeks of medication and decreased fractional anisotropy (FA) values in the right middle frontal cortex than subjects without the T allele. Subjects with the C allele at the MspI polymorphism showed decreased FA values in the right postcentral gyrus than subjects without.

Abstract Teaser
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FIGURE 1. Post-Treatment Percent Changes in Continuous Performance Test by MspI and DraI Genotypes of the α2A-Adrenergic Receptor Gene

The figure only includes results that differed among genotype groups at p value ≤0.10.

FIGURE 2. Brain Areas With Significantly Decreased Fractional Anisotropy Values in Subjects With the DraI C/T or T/T Genotype, as Compared With Those With the DraI C/C Genotype at the Voxel-Level Inference

Uncorrected p <0.0005.

FIGURE 3. Brain Areas With Significantly Decreased Fractional Anisotropy Values in Subjects With the MspI C/G or C/C Genotype, as Compared With Those With the MspI G/G Genotype at Voxel-Level Inference

Uncorrected p <0.0005.

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TABLE 1.Demographic and Clinical Characteristics of ADHD Subjects According to MspI and DraI Genotypes of α2A-Adrenergic Receptor Gene
Table Footer Note

ADHD: attention-deficit hyperactivity disorder; ADHD-RS: ADHD-Rating Scale.

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TABLE 2.Posttreatment Percent Changes by MspI and DraI Genotypes of α2A-Adrenergic Receptor Gene
Table Footer Note

a adjusted for age, IQ, and attention-deficit hyperactivity disorder-rating scale scores.

Table Footer Note

Posttreatment percent change calculated using [(post-treatment CPT score − baseline CPT score)/baseline CPT score] * 100.

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TABLE 3.Brain Region Showing Significant Differences in the Fractional Anisotropy Values by DraI or MspI Polymorphisms of the α2A-Adrenergic Receptor Gene
Table Footer Note

a Local maximal clusters composed of more than 100 significant voxels (p <0.0005), height-threshold.

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