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Clinical and Research Reports   |    
Agomelatine Treatment of Major Depressive Disorder in Parkinson's Disease: A Case Series
Domenico De Berardis, M.D., Ph.D.; Michele Fornaro, M.D.; Nicola Serroni, M.D.; Luigi Olivieri, M.D.; Stefano Marini, M.D.; Francesco Saverio Moschetta, M.D.; Venkataramanujam Srinivasan, Ph.D.; Maurizio Assetta, M.D.; Alessandro Valchera, M.D.; Anatolia Salone, M.D., Ph.D.; Giovanni Martinotti, M.D., Ph.D.; Marco Onofrj, M.D.; Massimo Di Giannantonio, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2013;25:343-345. doi:10.1176/appi.neuropsych.12110286
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All authors have equally contributed to the present case series.

Conflicts of Interest and Source of Funding: The authors have no conflict of interest to declare.

From NHS, Dept. of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini,” Teramo, Italy (DDB, NS, LO, SM, FSM), Dept. of Neuroscience and Imaging, University “G. D’Annunzio,” Chieti, Italy (DDB, SM, AS, GM, MDG), Dept. of “Scienze della Formazione,” University of Catania, Italy (MF), Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, Tamilnadu, India (VS), U.O.C. Neurology, Hospital “G. Mazzini,” ASL 4 Teramo, Italy (MA), Villa San Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy (AV), Dept. of Neuroscience and Imaging, Neurology, University “G. D’Annunzio,” Chieti, Italy (MO).

Send correspondence to Dr. De Berardis; e-mail: dodebera@aliceposta.it

Copyright © 2013 by the American Psychiatric Association

Received November 22, 2012; Revised March 21, 2013; Accepted April 08, 2013.


Major Depressive Disorder (MDD) is among the most frequent comorbidities occurring in the course of Parkinson’s disease (PD), and therefore, most PD patients receive antidepressant drugs. Agomelatine is a recently introduced antidepressant drug acting as an MT1/MT2 melatonergic receptor agonist and 5HT2C/5HT2B serotonergic antagonist. The aim of this case series was to evaluate the role of agomelatine in the treatment of MDD associated with PD.

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