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Clinical and Research ReportsFull Access

Agomelatine Treatment of Major Depressive Disorder in Parkinson's Disease: A Case Series

Published Online:1 Oct 2013https://doi.org/10.1176/appi.neuropsych.12110286

Abstract

Major Depressive Disorder (MDD) is among the most frequent comorbidities occurring in the course of Parkinson’s disease (PD), and therefore, most PD patients receive antidepressant drugs. Agomelatine is a recently introduced antidepressant drug acting as an MT1/MT2 melatonergic receptor agonist and 5HT2C/5HT2B serotonergic antagonist. The aim of this case series was to evaluate the role of agomelatine in the treatment of MDD associated with PD.