Structural deficits in the frontotemporal network have been shown in individuals with psychopathy and are posited to contribute to neuropsychological impairments such as response perseveration. However, no study to date has examined structural correlates of response perseveration in individuals with psychopathy. In this structural MRI study, the authors found higher correlations between increased response perseveration and reduced cortical thickness in the orbitofrontal and anterior temporal regions in individuals with psychopathy than in healthy-comparison subjects. The findings provide preliminary evidence suggesting potential contributions of frontotemporal structural deficits in neurocognitive impairment with perseveration in individuals with psychopathy.

Volume 23
Issue 1

Winter 2011
Pages 107-110

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This study was supported by a grant to the first author from the NIMH (1F31MH079592) and a grant to the second author from the National Institute of Child Health and Development (I RO1 HD42259). Research grants from the National Center for Research Resources, the NIH through the NIH Roadmap for Medical Research supported contributions of the UCLA co-authors. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIMH or the NIH.

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History

Received 14 July 2009

Accepted 2 November 2009

Published online 1 January 2011

Published in print 1 January 2011

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Abnormal Structural Correlates of Response Perseveration in Individuals With Psychopathy

Abstract