Mild traumatic brain injury (mTBI) is a complex entity with no known objective diagnostic markers. To test the hypothesis that sleep disturbances in the acute mTBI period can serve as an indicator of brain injury, the authors compared sleep polysomnograms (PSG) and sleep EEG power spectra (PS) data in seven mTBI subjects with seven age- and race-matched healthy-control subjects. The two groups differed significantly on PS measures, suggesting that mTBI can result in a disruption of sleep microarchitecture and, in theory, could be of use as a marker for brain injury. These pilot findings need to be replicated on larger samples.

Volume 23
Issue 2

Spring 2011
Pages 201-205

Metrics

We thank Dr. Naresh Punjabi for his consultative advice on power spectral analyses, Francis P. Sgambati for assistance with sleep data analyses, and the CRU/ICTR nursing staff for their participation in the execution of these studies.

This work was supported by K23 MH 066894 from the NIMH (Rao) DA16563 (McCann); and NCRR grant M01RR002719 (Ford). Dr. Rao has a grant from Forest to conduct a clinical trial in post-TBI depression and a grant from Pfizer to conduct a clinical trial in post-stroke anxiety. Dr. McCann served as a speaker for Jazz Pharmaceuticals in 2008 and received $14,000 for speaking engagements. She also served as an expert legal witness in an ongoing legal case and has received $18,000 for her services. Ms. Bergey is a research assistant on many studies supported by pharmaceutical companies (Merck, Forest, Elan, Pfizer, Eli Lilly).

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History

Received 3 February 2010

Revised 14 April 2010

Accepted 16 May 2010

Published online 1 April 2011

Published in print 1 April 2011

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Sleep Disturbance After Mild Traumatic Brain Injury: Indicator of Injury?

Abstract