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Association Between Clinical Measures and Florbetapir F18 PET Neuroimaging in Mild or Moderate Alzheimer’s Disease Dementia
Michael M. Witte, Ph.D.; Paula Trzepacz, M.D.; Michael Case, M.S.; Peng Yu, Ph.D.; Helen Hochstetler, Pharm.D.; Mitchell Quinlivan, Ph.D.; Karen Sundell, B.S.; David Henley, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;:. doi:10.1176/appi.neuropsych.12120402
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From the Department of Neurosciences, Lilly USA, LLC, Indianapolis, IN (MMW, PT, MC, PY, HH); the Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN (PT, DH); Eli Lilly Australia, West Ryde, Australia (MQ); and Lilly Research Laboratories, Indianapolis, IN (KS, DH).

Send correspondence to Dr. Witte; e-mail: witte_michael_m@lilly.com

The authors report that they are employees of Eli Lilly and Company. All authors except Dr. Quinlivan are minor shareholders of Eli Lilly and Company.

Copyright © 2014 by the American Psychiatric Association

Received December 18, 2012; Revised March 21, 2013; Accepted April 22, 2013.

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Abstract

Clinical diagnosis of Alzheimer’s disease (AD) is challenging with 20% or more of patients misdiagnosed, even by expert clinicians. We conducted a retrospective, cross-sectional analysis comparing baseline neuropsychiatric and other clinical characteristics in 199 expert-diagnosed mild and moderate AD dementia patients participating in industry-sponsored clinical trials of an investigational therapy, where 18% lacked florbetapir positron emission tomography (PET) evidence of AD neuropathology. Significant differences were found only for cognition and ApoE ε4 status, but the large degree of score overlap would preclude using these measures to predict AD misdiagnosis. This study highlights the value of amyloid PET when evaluating patients with seemingly typical AD.

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