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Clinical and Research Reports   |    
Inefficacy of Antipsychotics in Treatment of Delirium and Agitation in Two Cases of Bickerstaff Brainstem Encephalitis
Abdulkader Alam, M.D.; Neil V. Puri, M.D.
The Journal of Neuropsychiatry and Clinical Neurosciences 2014;26:176-178. doi:10.1176/appi.neuropsych.13040078
View Author and Article Information

The authors report no financial relationships with commercial interests.

From the Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Send correspondence to Dr. Alam; e-mail:al.alam@stonybrookmedicine.edu

Previously presented at the 59th Annual Conference of the Academy of Psychosomatic Medicine, November 15, 2012, Atlanta.

Copyright © 2014 by the American Psychiatric Association

Received April 04, 2013; Revised July 01, 2013; Accepted July 01, 2013.

Abstract

The authors report two unusual cases of Bickerstaff encephalitis that presented with encephalopathy and severe agitation. Management with neuroleptics typically used for management of delirium was not effective and worsened agitation. Valproic acid was effective in treatment of agitation and well tolerated.

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