Recent neuropathological and magnetic resonance imaging (MRI) studies
have demonstrated developmental disturbances of neuronal migration in the
cerebral cortex of autistic subjects. We report neuroradiological findings
in two patients with Asperger's syndrome, a less severe variant of autism.
One patient had left frontal macrogyria; the other had bilateral opercular
polymicrogyria. A computer tomography (CT) scan performed on one of the
patients' first-degree relatives (who had a bipolar disease) also showed
cortical migration anomalies.