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The Journal of Neuropsychiatry and Clinical Neurosciences, VOL. 5, No. 3

Article | August 01, 1993

Human brain fluoxetine concentrations

The Journal of Neuropsychiatry and Clinical Neurosciences 1993;5:322-329.

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Abstract

Data on 22 subjects treated with fluoxetine suggest that magnetic resonance spectroscopy (MRS) of fluorine-19 can measure brain concentrations of fluoxetine/norfluoxetine in vivo. Fluoxetine accumulates in the human brain relative to plasma, with brain concentrations of fluoxetine/norfluoxetine ranging up to 10.7 micrograms/ml. Brain concentrations may reach a plateau between 6 and 8 months of treatment. The apparent concentration in brain relative to plasma is 20:1, roughly parallel to brain antidepressant concentration ratios in animal studies.

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