In a study of 45 patients with anxiety disorders and 11 control
subjects, mean cerebrospinal fluid (CSF) concentrations of thyrotropin-
releasing hormone (TRH) were not significantly different between
nonpsychiatric control subjects and those with panic disorder, generalized
anxiety disorder, or obsessive-compulsive disorder. Male subjects,
regardless of diagnosis, had significantly higher mean CSF concentrations
of TRH than females.