This article provides a broad theoretical and clinical overview of the
three regional prefrontal syndromes. An understanding of the extended
neural connectivity of the prefrontal cortex provides the template for
describing the three distinct prefrontal syndromes (dysexecutive,
disinhibited, and apathetic types), each associated with dysfunction in one
of the three prefrontal regions. This clinical approach should aid the
clinician in determining the etiology of the specific regional prefrontal
syndrome and developing effective treatment strategies.