Sertraline, a selective serotonin reuptake inhibitor, was used to treat
two consecutive cases of genetically confirmed Huntington's disease in
which severe irritability and aggressiveness required inpatient admission.
The complete cessation of aggressive behavior in both cases has been
maintained on follow-up. This report adds to the literature implicating
serotonergic mechanisms in irritability and aggressiveness in both
neuropsychiatric and idiopathic psychiatric disorders.