Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Article   |    
Effect of amantadine hydrochloride on symptoms of frontal lobe dysfunction in brain injury: case studies and review
The Journal of Neuropsychiatry and Clinical Neurosciences 1997;9:222-230.
text A A A
PDF of the full text article.


Symptoms consistent with dysfunction of the frontal lobes can occur following traumatic brain injury (TBI) or other types of acquired brain injury (stroke, aneurysm). These symptoms can include problems with short-term memory, attention, planning, problem solving, impulsivity, disinhibition, poor motivation, and other behavioral and cognitive deficits ("frontal lobe syndrome"). These symptoms may respond to certain drugs, such as dopaminergic agents. This case series describes results of using amantadine in 7 patients with this type of symptom profile (6 with TBI, 1 with meningitis following sinus surgery). Patients received neuropsychiatric examinations and serial neuropsychological testing. All patients showed some degree of positive response. One had side effects that resolved upon discontinuation of drug. The rationale for using dopaminergics is discussed, and pertinent literature is reviewed.

Abstract Teaser
Figures in this Article




CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe

Web of Science® Times Cited: 61

Related Content
Textbook of Traumatic Brain Injury, 2nd Edition > Chapter 17.  >
Textbook of Traumatic Brain Injury, 2nd Edition > Chapter 20.  >
Textbook of Traumatic Brain Injury, 2nd Edition > Chapter 20.  >
Textbook of Traumatic Brain Injury, 2nd Edition > Chapter 35.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 11.  >
Topic Collections
Psychiatric News
Read more at Psychiatric News >>
PubMed Articles