Twenty patients with HIV infection and mania were grouped according to
whether their first manic episode occurred when CD4 count was < 200
(late onset) or > or = 200 (early onset). The late-onset patients were
less likely to have personal or family histories of mood disorder and more
likely to have dementia or cognitive slowing. They also exhibited a
different manic symptom profile. The different sociodemographic and symptom
profiles associated with early-onset and late-onset mania may reflect
differences in pathophysiology.