The authors retrospectively reviewed the charts of 29 inpatients with
AIDS and 24 medically ill inpatients, all of whom were exposed to
neuroleptics. Results adjusted for age, gender, type and dosage of
neuroleptic, and extrapyramidal prophylaxis indicated that inpatients with
AIDS were 7 times more likely to develop extrapyramidal syndromes (EPS)
from neuroleptics than the comparison group of medically ill inpatients.
Possible neuroanatomic, neuropathologic, and neurochemical reasons for the
vulnerability of patients with AIDS to EPS are reviewed.