J Neuropsychiatry Clin Neurosci 1989; 1:53-56
Copyright © 1989 by American Neuropsychiatric Association
Metoclopramide fails to suppress linguopharyngeal events in a rat dyskinesia model
LA Marco, TF Reed, RS Joshi, LD Aldes and RB Chronister
Department of Psychiatry, College of Medicine, University of South Alabama, Mobile 36617.
The effects of metoclopramide on ketamine-induced linguopharyngeal events
exemplified by tongue retrusions, protrusions, and swallowing acts were
tested in ketamine-anesthetized rats mounted on a stereotaxic frame with
the tip of the tongue tied to a force displacement transducer to monitor
retrusion and protrusion and a pressure transducer inserted into the mouth
at the level of the soft palate to monitor swallowing. Metoclopramide at
doses ranging from 0.5 to 50 mg/kg im failed to decrease protrusions,
retrusions, or swallowing. It rather increased all three events for up to
2.5 hours. The significance of these findings is discussed.
