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J Neuropsychiatry Clin Neurosci 1989; 1:128-134
Copyright © 1989 by American Neuropsychiatric Association
Temporal lobe measurement in primary affective disorder by magnetic resonance imaging
P Hauser, LL Altshuler, W Berrettini, ID Dauphinais, J Gelernter and RM Post
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20892.
Magnetic resonance imaging brain scans were performed on 17 patients with
primary affective disorder and 21 normal subjects. A coronal slice through
the temporal lobes at the level of the pons and interpeduncular cistern was
selected in each subject, and specific temporal lobe structures and the
cerebral area were measured. Ratios between structures of the same
hemisphere were calculated. The ratio of the temporal lobe to cerebral area
was smaller in patients than controls both on the left (p less than .02)
and on the right (p less than .03). The data suggest that patients with
primary affective disorder may have a relative decrease in the size of the
temporal lobe compared with normal controls.
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