The effect of apomorphine on regional cerebral blood flow in schizophrenia



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J Neuropsychiatry Clin Neurosci 1989; 1:377-384
Copyright © 1989 by American Neuropsychiatric Association

RANDOMIZED CONTROLLED TRIAL

The effect of apomorphine on regional cerebral blood flow in schizophrenia

DG Daniel, KF Berman and DR Weinberger
Clinical Brain Disorders Branch, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032.

A double-blind, placebo-controlled crossover study of the effects of apomorphine on regional cerebral blood flow (rCBF) during a prefrontal cortex activation task was undertaken to explore the role of dopamine on cortical function. The subjects were eight drug-free, chronically psychotic patients; six patients had schizophrenia. In each, apomorphine increased the relative prefrontal flow. The results suggest that enhanced prefrontal dopamine activity may reverse deficits in prefrontal cortex metabolism in schizophrenia.

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