Axonal counts of the corpus callosum of schizophrenic patients



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J Neuropsychiatry Clin Neurosci 1989; 1:391-393
Copyright © 1989 by American Neuropsychiatric Association

REGULAR ARTICLES

Axonal counts of the corpus callosum of schizophrenic patients

MF Casanova, M Zito, LB Bigelow, B Berthot, RD Sanders and JE Kleinman
Clinical Brain Disorders Branch, National Institute of Mental Health, Washington, D.C.

This study attempted to identify microscopic correlates to the structural abnormalities reported in the corpus callosum of schizophrenic patients. Sections of the genu, body, and splenium of the corpus callosum were taken from formalin-fixed brains of deceased patients with schizophrenia and nonschizophrenic control subjects. Photomicrographs of stained tissue were projected, and nerve fibers were counted. There were no significant differences (p greater than 0.4) in axonal counts between schizophrenic and control patients for any of the sites sampled. Our results suggest that morphometric abnormalities of the corpus callosum of schizophrenic patients, if present, are not the consequence of a primary process within this structure.

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