Brain iron in progressive supranuclear palsy: clinical, magnetic resonance imaging, and neuropathological findings



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	Articles by Coffey, C. E.
	Articles by Burger, P. C.

J Neuropsychiatry Clin Neurosci 1989; 1:400-404
Copyright © 1989 by American Neuropsychiatric Association

REGULAR ARTICLES

Brain iron in progressive supranuclear palsy: clinical, magnetic resonance imaging, and neuropathological findings

CE Coffey, S Alston, ER Heinz and PC Burger
Department of Medicine (Neurology), Duke University Medical Center, Durham, NC 27710.

A patient with progressive supranuclear palsy demonstrated a region- specific decrease in T2 signal during high-field-strength brain magnetic resonance imaging. At autopsy the T2-signal hypointensity was found to correspond topographically to increased deposition of ferric iron. The potential clinical, radiologic, and pathophysiologic implications of these findings are discussed.

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