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Magnetic Resonance Spectroscopy in Affective Disorders

Received September 18, 1996; revised December 2, 1996; accepted February 13, 1997. From the Department of Psychiatry and Molecular Neurobiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan. Address correspondence to Dr. Kato, Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo, Tokyo, 113-8655, Japan; e-mail: tadafumi-tky{at}umin.ac.jp

Magnetic resonance spectroscopy (MRS) is a noninvasive tool for in vivo chemical analysis that has been applied to neurobiological or psychopharmacological studies of affective disorders. Studies employing ³¹P-MRS and ¹H-MRS have indicated possible abnormalities in membrane phospholipid metabolism, high-energy phosphate metabolism, and intracellular pH in affective disorders. They have also suggested that lithium increases the phosphomonoester (possibly inositol-1-phosphate) peak in the brain but does not increase that of choline-containing compounds in the brain. Studies employing ⁷Li-MRS and ¹⁹F-MRS have elucidated the pharmacokinetic properties of lithium, fluoxetine, and fluvoxamine in the brain in patients treated with these drugs.

Key Words: Bipolar Disorder • Depression • Magnetic Resonance Spectroscopy

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