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Age-Related Changes in Brain Glucose Metabolism in Adults With Attention-Deficit/Hyperactivity Disorder and Control Subjects

Received April 10, 1997; revised July 10, 1997; accepted July 23, 1997. From the Laboratory of Cerebral Metabolism and the Office of the Clinical Director, National Institute of Mental Health, Rockville, Maryland; and the Brain Imaging Center, National Institute on Drug Abuse, Baltimore, Maryland. Address correspondence to Dr. Ernst, The Laboratory of Cerebral Metabolism, Building 36, Convent Drive, MSC 4030, Baltimore, MD 20892-4030.

Using positron emission tomography and [¹⁸F]-2-fluoro-2-deoxy-D-glucose, the authors determined cerebral metabolic rates for glucose (CMRglc) in 39 adults (18–51 years old) with attention-deficit/hyperactivity disorder (ADHD) and 56 healthy control adults (19–56 years old) during the performance of a continuous attention task. Increased age was associated with reduced global CMRglc in ADHD women, but not in ADHD men, control men, or control women. Better performance on the attention task was significantly associated with increased age only in the ADHD female group. Determining the role of behavioral, hormonal, and genetic factors is a challenge for future research.

Key Words: Attention-Deficit/Hyperactivity Disorder • Gender • Cerebral Blood Flow and Metabolism

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				K. K. S. Voeller Attention-Deficit Hyperactivity Disorder (ADHD) J Child Neurol, October 1, 2004; 19(10): 798 - 814. [Abstract] [PDF]

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