
J Neuropsychiatry Clin Neurosci 10:199-204, May 1998
© 1998 American Psychiatric Press, Inc.
Is Delirium Different When It Occurs in Dementia?
A Study Using the Delirium Rating Scale
Paula T. Trzepacz, M.D.,
Benoit H. Mulsant, M.D.,
Mary Amanda Dew, Ph.D.,
Rona Pasternak, M.D.,
Robert A. Sweet, M.D. and
George S. Zubenko, M.D., Ph.D.
Received August 20, 1996; revised April 21, 1997; accepted April 25, 1997. From the Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, and the Divisions of Geriatric Psychiatry/Neuropsychiatry and Psychiatric Epidemiology, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center/University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Address correspondence to Dr. Trzepacz, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS 39216.
The authors studied 61 geropsychiatric patients with delirium from a cohort of 843 consecutive admissions to a geriatric clinical research unit. A central study goal was to assess how the presence of dementia affected the presentation of delirium. Eighteen delirious (D) and 43 delirious-demented (D-D) patients were compared on the Delirium Rating Scale (DRS), Mini-Mental State Examination (MMSE), Brief Psychiatric Rating Scale (BPRS), and EEG. D-D patients had lower MMSE scores, but no differences were found in total DRS or BPRS scores or in EEG grade. DRS items were similar in the two groups except that D-D had more cognitive impairment than D. An exploratory principal components analysis of DRS items identified two core factors. The authors conclude that the presentation of delirium in the setting of concurrent dementia is very similar to delirium without dementia, with subtle differences probably attributable to dementia.
Key Words: Delirium Dementia Rating Scales
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