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* Parkinson's Disease
J Neuropsychiatry Clin Neurosci 10:216-219, May 1998
© 1998 American Psychiatric Press, Inc.


Clinical and Research Report

Quetiapine (Seroquel) in the Treatment of Psychosis in Patients With Parkinson's Disease

Mahmoud A. Parsa, M.D. and Bijan Bastani, M.D.

Received February 19, 1997; revised May 15, 1997; accepted May 20, 1997. From the Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio. Address correspondence to Dr. Parsa, Department of Psychiatry, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106.

Psychoses are a common clinical problem in patients with Parkinson's disease. Treatment with typical neuroleptics or withdrawal of antiparkinsonian drugs may improve mental symptoms but will worsen the parkinsonism. Quetiapine (Seroquel), ICI 204,636, is a novel antipsychotic medication with a low potential for producing extrapyramidal side effects. In this open-label clinical study of 2 patients with Parkinson's disease, treatment with Seroquel successfully controlled psychotic symptoms without worsening of motor disability.

Key Words: Quetiapine • Antipsychotic Medications • Parkinson's Disease




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