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A Preliminary Study of D-Cycloserine Treatment in Alzheimer's Disease

Received November 8, 1996; revised Februray 3, 1997; accepted February 5, 1997. From the Geriatric Neurobehavioral Clinic and Laboratory of Molecular and Developmental Neuroscience, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts. Address correspondence to Dr. Tsai, Milman Research Center, McLean Hospital, Belmont, MA 02178; e-mail: TSAIG{at}Helix.MGH.Harvard.EDU

D-cycloserine is a partial agonist on the glycine site of the N-methyl-D-aspartate glutamate receptor. This double-blind crossover study of 15 mg D-cycloserine in Alzheimer's disease patients did not demonstrate clinical benefit. Higher medication dosage or long-term treatment may be required.

Key Words: D-cycloserine • N-methyl-D-aspartate • Alzheimer's Disease

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